Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/SST1/Gqi5 Stable Cell L
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner SST1 receptor is a Gi/Go-coupled GPCR which is expressed in pancreatic islets pituitary Cerebellum (Purkinje cells) frontal cortex (pyramidal cells) hippocampus (CA1-4 subfields and some granule cells of the dentate gyrus) It inhibits cAMP accumulation and stimulates tyrosine phosphatase activity it also can antiproliferation br GenScript s SST1-expressing stable cell line was made in CHO-K1/Gqi5 host cell and optimized for calcium assays
Genscript Corporation CHO-K1/Lag3 Stable Cell Line
Lymphocyte-activation gene 3 also known as LAG-3 is a protein which in humans is encoded by the LAG3 gene [1] LAG3 which was discovered in 1990[2] and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000[3] LAG-3 is a cell surface molecule with diverse biologic effects on T cell function It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders
Genscript Corporation CHO-K1/ mouse PD-1 Stable Cell
Programmed cell death protein 1 also known as PD-1 and CD279 (cluster of differentiation 279) is a protein that in humans is encoded by the PDCD1 gene PD-1 functioning as an immune checkpoint plays an important role in down regulating the immune system by preventing the activation of T-cells which in turn reduces autoimmunity and promotes self-tolerance The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells)
Genscript Corporation CHO-K1/ACE2 Stable Cell Line
Recombinant CHO-K1 cells stably express Angiotensin-converting enzyme 2 (ACE2) on the cell surface The surface expression of ACE2 is validated by FACS analysis This stable cell line product is designed for cell-based binding assays that measure binding affinity and stability of antibody based biologics binding with ACE2
Genscript Corporation CHO-K1/cyno CTLA4 Stable Cell
CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) also known as CD152 (cluster of differentiation 152) is a protein receptor that functioning as an immune checkpoint downregulates immune responses CTLA4 is constitutively expressed in Tregs but only upregulated in conventional T cells after activation It acts as an
Genscript Corporation B7-H3 4Ig /B7-H3b hFc Chimer
B7-H3 a member of the B7 family of immunomodulatory molecules is overexpressed in a wide range of solid cancers B7-H3 binds to activated T cells via an as yet unidentified receptor In assays using sub-optimal amount so anti-CD3 stimulation 2Ig B7 H3 enhances T cell proliferation T cell interferon-gamma (IFN-gamma) production and cytotoxic T cells induction
Genscript Corporation CHO-K1/BDCA2 and FcER1G Stable
Recombinant CHO-K1 cells stably overexpress human C-type lectin domain family 4 member C (BDCA2) and Fc epsilon receptor Ig (FcER1G) on the surface The surface expression of BDCA2 is validated by FACS analysis
Genscript Corporation CHO-K1/BDCA2 Stable Cell Line
BDCA-2 is a novel type II C-type lectin which shows 50 7% sequence identity at the amino acid level to its putative murine ortholog the murine dendritic cell associated C-type lectin 2 In addition to its antigen capturing function BDCA-2 can mediate potent inhibition of induction of IFN- / expression in PDCs Production of IFN- / in response to several different types of viruses bacteria CpG-DNA dsRNA and SLE serum is by far the most prominent feature of PDCs
Genscript Corporation CHO-K1/Cyno CD47 Stable Cell L
This gene encodes a membrane protein which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin and it may play a role in membrane transport and signal transduction This gene has broad tissue distribution and is reduced in expression on Rh erythrocytes Alternatively spliced transcript variants have been found for this gene
Genscript Corporation HEK293/CLDN18.2 Stable Cell Li
Claudins are a family of proteins which play a role in maintaining tight cell junctions Differentclaudin subtypes are expressed on different tissues Claudin18 isoform 2 (CLDN18 2) expressionin normal tissues is restricted to cells of the gastric mucosa and is absent from other healthytissues However CLDN 18 2 is expressed in 70% of primary gastric adenocarcinomas and itsmetastases (101) It has also beenshown to be expressed in a number of other cancers including pancreatic (50%) esophagus (30%) and NSCLC (25%)The restricted expressionmakes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma asevidenced by effortsto target CLDN18 2 via naked antibody and CAR-T modalities
Genscript Corporation CHO-K1/ADRA1D Stable Cell Line
Recombinant CHO-K1 cells stably overexpress human adrenoceptor alpha 1D (ADRA1D) on the surface and contain high levels of G protein G q to couple with the receptor in downstream signaling pathways
Revvity Health Sciences Inc HTRF Tag-Lite CXCR4 (HEK293) Receptor Cell line
HTRF Tag-Lite CXCR4 (HEK293) Receptor Cell line
Revvity Health Sciences Inc Tag-lite Vasopressin V2 receptor Frozen & Labeled Cells, 200 Assay Points
Tag-lite Vasopressin V2 receptor Frozen & Labeled Cells, 200 Assay Points
Sartorius Human Multi Ab Internalization
No wash protocol- fast easy antibody-labeling method optimal for screening antibody internalization.High throughput evaluation of antibody internalization- Assay designed to measure internalization of a large number of antibodies in 96- and 384-well plate formats using 10 L of cells and 10 L of labeled antibody kit .Simultaneously measure antibody internalization cell specificity and cell health within the same well.PrincipleAntibodies are easily labeled with Intellicyt Antibody Internalization Reagent a novel pH sensitive dye.
Cayman Chemical Acylated Ghrelin human Expre
This EIA kit specifically measures the acylated form of ghrelin.
